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1

A Rap/Phosphatidylinositol 3-Kinase Pathway Controls Pseudopod Formation

Kortholt, A., Bolourani, P., Rehmann, H., Keizer-Gunnink, I., Weeks, G., Wittinghofer, A., Van Haastert, P. J.M.

Journal:

Molecular Biology of the Cell

Year:

2010

Language:

english

File:

PDF, 1.52 MB

english, 2010

2

Coupled excitable Ras and F-actin activation mediates spontaneous pseudopod formation and directed cell movement

van Haastert, Peter J. M., Keizer-Gunnink, Ineke, Kortholt, Arjan, Parent, Carole

Journal:

Molecular Biology of the Cell

Year:

2017

Language:

english

File:

PDF, 1.24 MB

english, 2017

3

Regulation of Phagocytosis in Dictyostelium by the Inositol 5-Phosphatase OCRL Homolog Dd5P4

Harriët M. Loovers, Arjan Kortholt, Hendrie de Groote, Leslie Whitty, Robert L. Nussbaum, Peter J. M. van Haastert

Journal:

Year:

2007

Language:

english

File:

PDF, 490 KB

english, 2007

4

Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase

Gotthardt, Katja, Weyand, Michael, Kortholt, Arjan, Van Haastert, Peter J M, Wittinghofer, Alfred

Journal:

The EMBO Journal

Year:

2008

Language:

english

File:

PDF, 1.82 MB

english, 2008

5

Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase

Gotthardt, Katja, Weyand, Michael, Kortholt, Arjan, Van Haastert, Peter J M, Wittinghofer, Alfred

Journal:

The EMBO Journal

Year:

2008

Language:

english

File:

PDF, 37 KB

english, 2008

6

Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs

Kae, Helmut, Kortholt, Arjan, Rehmann, Holger, Insall, Robert H, Van Haastert, Peter J M, Spiegelman, George B, Weeks, Gerald

Journal:

Year:

2007

Language:

english

File:

PDF, 168 KB

english, 2007

7

Highlighting the role of Ras and Rap during Dictyostelium chemotaxis

Arjan Kortholt, Peter J.M. van Haastert

Journal:

Cellular Signalling

Year:

2008

Language:

english

File:

PDF, 402 KB

english, 2008

8

Ras activation and symmetry breaking during Dictyostelium chemotaxis

Kortholt, A., Keizer-Gunnink, I., Kataria, R., Van Haastert, P. J. M.

Journal:

Journal of Cell Science

Year:

2013

Language:

english

File:

PDF, 2.19 MB

english, 2013

9

Simple system – substantial share: The use of Dictyostelium in cell biology and molecular medicine

Müller-Taubenberger, Annette, Kortholt, Arjan, Eichinger, Ludwig

Journal:

European Journal of Cell Biology

Year:

2013

Language:

english

File:

PDF, 861 KB

english, 2013

10

Essential Role of PI3-Kinase and Phospholipase A2 in Dictyostelium discoideum Chemotaxis

Peter J. M. van Haastert, Ineke Keizer-Gunnink and Arjan Kortholt

Journal:

The Journal of Cell Biology

Year:

2007

Language:

english

File:

PDF, 1.26 MB

english, 2007

11

Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations

Gilsbach, B. K., Ho, F. Y., Vetter, I. R., van Haastert, P. J. M., Wittinghofer, A., Kortholt, A.

Journal:

Proceedings of the National Academy of Sciences

Year:

2012

Language:

english

File:

PDF, 1.19 MB

english, 2012

12

Chemoattractants and chemorepellents act by inducing opposite polarity in phospholipase C and PI3-kinase signaling

Keizer-Gunnink, I., Kortholt, A., Van Haastert, P. J.M.

Journal:

The Journal of Cell Biology

Year:

2007

Language:

english

File:

PDF, 1.20 MB

english, 2007

13

Dictyostelium Ric8 is a nonreceptor guanine exchange factor for heterotrimeric G proteins and is important for development and chemotaxis

Kataria, R., Xu, X., Fusetti, F., Keizer-Gunnink, I., Jin, T., van Haastert, P. J. M., Kortholt, A.

Journal:

Proceedings of the National Academy of Sciences

Year:

2013

Language:

english

File:

PDF, 740 KB

english, 2013

14

Characterization of the GbpD-activated Rap1 Pathway Regulating Adhesion and Cell Polarity in Dictyostelium discoideum

Kortholt, A., Rehmann, H., Kae, H., Bosgraaf, L., Keizer-Gunnink, I., Weeks, G., Wittinghofer, A., Van Haastert, P. J. M.

Journal:

Journal of Biological Chemistry

Year:

2006

Language:

english

File:

PDF, 888 KB

english, 2006

15

Revisiting the Roco G-protein cycle

Terheyden, Susanne, Ho, Franz Y., Gilsbach, Bernd K., Wittinghofer, Alfred, Kortholt, Arjan

Journal:

Biochemical Journal

Year:

2015

Language:

english

File:

PDF, 1.05 MB

english, 2015

16

Intramolecular Activation Mechanism of the Dictyostelium LRRK2 Homolog Roco Protein GbpC

van Egmond, W. N., Kortholt, A., Plak, K., Bosgraaf, L., Bosgraaf, S., Keizer-Gunnink, I., van Haastert, P. J. M.

Journal:

Journal of Biological Chemistry

Year:

2008

Language:

english

File:

PDF, 975 KB

english, 2008

17

Phospholipase C Regulation of Phosphatidylinositol 3,4,5-trisphosphate-mediated Chemotaxis

Kortholt, A., King, J. S., Keizer-Gunnink, I., Harwood, A. J., Van Haastert, P. J.M.

Journal:

Molecular Biology of the Cell

Year:

2007

Language:

english

File:

PDF, 827 KB

english, 2007

18

Multiple Regulatory Mechanisms for the Dictyostelium Roco Protein GbpC

Kortholt, A., van Egmond, W. N., Plak, K., Bosgraaf, L., Keizer-Gunnink, I., van Haastert, P. J. M.

Journal:

Journal of Biological Chemistry

Year:

2012

Language:

english

File:

PDF, 2.99 MB

english, 2012

19

DdPDE4, a Novel cAMP-specific Phosphodiesterase at the Surface of Dictyostelium Cells

Bader, S., Kortholt, A., Snippe, H., Van Haastert, P. J. M.

Journal:

Journal of Biological Chemistry

Year:

2006

Language:

english

File:

PDF, 1.16 MB

english, 2006

20

Daydreamer, a Ras effector and GSK-3 substrate, is important for directional sensing and cell motility

Kolsch, V., Shen, Z., Lee, S., Plak, K., Lotfi, P., Chang, J., Charest, P. G., Romero, J. L., Jeon, T. J., Kortholt, A., Briggs, S. P., Firtel, R. A.

Journal:

Molecular Biology of the Cell

Year:

2013

Language:

english

File:

PDF, 9.10 MB

english, 2013

21

Structural Characterization of LRRK2 Inhibitors

Gilsbach, Bernd K., Messias, Ana C., Ito, Genta, Sattler, Michael, Alessi, Dario R., Wittinghofer, Alfred, Kortholt, Arjan

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 3.35 MB

english, 2015

22

Essential role of PI3-kinase and phospholipase A2 in Dictyostelium discoideum chemotaxis

van Haastert, P. J.M., Keizer-Gunnink, I., Kortholt, A.

Journal:

The Journal of Cell Biology

Year:

2007

Language:

english

File:

PDF, 1.17 MB

english, 2007

23

Reply to Tall et al.: Dictyostelium Ric8 does not have a chaperoning function during development and chemotaxis

Kataria, Rama, van Haastert, Peter J. M., Kortholt, Arjan

Journal:

Proceedings of the National Academy of Sciences

Year:

2013

Language:

english

File:

PDF, 485 KB

english, 2013

24

Homer3 regulates the establishment of neutrophil polarity

Wu, J., Pipathsouk, A., Keizer-Gunnink, A., Fusetti, F., Alkema, W., Liu, S., Altschuler, S., Wu, L., Kortholt, A., Weiner, O. D.

Journal:

Molecular Biology of the Cell

Year:

2015

Language:

english

File:

PDF, 1.04 MB

english, 2015

25

Rap1-dependent pathways coordinate cytokinesis in Dictyostelium

Plak, K., Keizer-Gunnink, I., van Haastert, P. J. M., Kortholt, A.

Journal:

Molecular Biology of the Cell

Year:

2014

Language:

english

File:

PDF, 6.90 MB

english, 2014

26

Chemoattractants and Chemorepellents Act by Inducing Opposite Polarity in Phospholipase C and Pl3-Kinase Signaling

Ineke Keizer-Gunnink, Arjan Kortholt and Peter J. M. Van Haastert

Journal:

The Journal of Cell Biology

Year:

2007

Language:

english

File:

PDF, 1.70 MB

english, 2007

27

Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification

Kortholt, Arjan, Kataria, Rama, Keizer-Gunnink, Ineke, Van Egmond, Wouter N, Khanna, Ankita, Van Haastert, Peter J M

Journal:

Year:

2011

Language:

english

File:

PDF, 786 KB

english, 2011

28

Direct Interaction between TalinB and Rap1 is necessary for adhesion ofDictyosteliumcells

Plak, Katarzyna, Pots, Henderikus, Van Haastert, Peter J. M., Kortholt, Arjan

Journal:

BMC Cell Biology

Year:

2016

Language:

english

File:

PDF, 2.27 MB

english, 2016

29

Seven Dictyostelium discoideum phosphodiesterases degrade three pools of cAMP and cGMP

Bader, Sonya, Kortholt, Arjan, Van Haastert, Peter J. M.

Journal:

Biochemical Journal

Year:

2007

Language:

english

File:

PDF, 567 KB

english, 2007

30

Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations

Rudi, K., Ho, F. Y., Gilsbach, B. K., Pots, H., Wittinghofer, A., Kortholt, A., Klare, J. P.

Journal:

Bioscience Reports

Year:

2015

Language:

english

File:

PDF, 1.25 MB

english, 2015

31

A Gα-Stimulated RapGEF Is a Receptor-Proximal Regulator of Dictyostelium Chemotaxis

Liu, Youtao, Lacal, Jesus, Veltman, Douwe M., Fusetti, Fabrizia, van Haastert, Peter J.M., Firtel, Richard A., Kortholt, Arjan

Journal:

Developmental Cell

Year:

2016

Language:

english

File:

PDF, 4.12 MB

english, 2016

32

Connecting G protein signaling to chemoattractant-mediated cell polarity and cytoskeletal reorganization

Liu, Youtao, Lacal, Jesus, Firtel, Richard A., Kortholt, Arjan

Journal:

Year:

2016

Language:

english

File:

PDF, 308 KB

english, 2016

33

The small GTPases Ras and Rap1 bind to and control TORC2 activity

Khanna, Ankita, Lotfi, Pouya, Chavan, Anita J., Montaño, Nieves M., Bolourani, Parvin, Weeks, Gerald, Shen, Zhouxin, Briggs, Steven P., Pots, Henderikus, Van Haastert, Peter J. M., Kortholt, Arjan, Ch

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 3.68 MB

english, 2016

34

The unconventional G-protein cycle of LRRK2 and Roco proteins

Terheyden, S., Nederveen-Schippers, L. M., Kortholt, A.

Journal:

Biochemical Society Transactions

Year:

2016

Language:

english

File:

PDF, 378 KB

english, 2016

35

Role of the small GTPase Rap1 in signal transduction, cell dynamics and bacterial infection

Hilbi, Hubert, Kortholt, Arjan

Journal:

Year:

2017

Language:

english

File:

PDF, 782 KB

english, 2017

36

The LRR-Roc-COR module of the Chlorobium tepidum Roco protein: crystallization and X-ray crystallographic analysis

Deyaert, Egon, Kortholt, Arjan, Versées, Wim

Journal:

Acta Crystallographica Section F Structural Biology Communications

Year:

2017

Language:

english

File:

PDF, 1.14 MB

english, 2017

37

GPCR-controlled membrane recruitment of negative regulator C2GAP1 locally inhibits Ras signaling for adaptation and long-range chemotaxis

Xu, Xuehua, Wen, Xi, Veltman, Douwe M., Keizer-Gunnink, Ineke, Pots, Henderikus, Kortholt, Arjan, Jin, Tian

Journal:

Proceedings of the National Academy of Sciences

Year:

2017

Language:

english

File:

PDF, 2.18 MB

english, 2017

38

The role of (auto)-phosphorylation in the complex activation mechanism of LRRK2

Athanasopoulos, Panagiotis S., Heumann, Rolf, Kortholt, Arjan

Journal:

Biological Chemistry

Year:

2017

Language:

english

File:

PDF, 560 KB

english, 2017

39

Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson’s Disease

Rosenbusch, Katharina E., Kortholt, Arjan

Journal:

Parkinson's Disease

Year:

2016

Language:

english

File:

PDF, 1.43 MB

english, 2016

40

Function and Regulation of Heterotrimeric G Proteins during Chemotaxis

Kamp, Marjon, Liu, Youtao, Kortholt, Arjan

Journal:

International Journal of Molecular Sciences

Year:

2016

Language:

english

File:

PDF, 2.02 MB

english, 2016

41

Structural biology of the LRRK2 GTPase and kinase domains: implications for regulation

Gilsbach, Bernd K., Kortholt, Arjan

Journal:

Frontiers in Molecular Neuroscience

Year:

2014

Language:

english

File:

PDF, 2.62 MB

english, 2014

42

Structure and nucleotide-induced conformational dynamics of the Chlorobium tepidum Roco protein

Deyaert, Egon, Leemans, Margaux, Singh, Ranjan Kumar, Gallardo, Rodrigo, Steyaert, Jan, Kortholt, Arjan, Lauer, Janelle, Versées, Wim

Journal:

Biochemical Journal

Year:

2018

Language:

english

File:

PDF, 8.20 MB

english, 2018

43

Roco Proteins: GTPases with a Baroque Structure and Mechanism

Wauters, Lina, Versées, Wim, Kortholt, Arjan

Journal:

International Journal of Molecular Sciences

Year:

2019

Language:

english

File:

PDF, 2.90 MB

english, 2019

44

Linalool attenuates oxidative stress and mitochondrial dysfunction mediated by glutamate and NMDA toxicity

Sabogal-Guáqueta, Angélica María, Hobbie, Fabian, Keerthi, Akshaya, Oun, Asmaa, Kortholt, Arjan, Boddeke, Erik, Dolga, Amalia

Journal:

Biomedicine & Pharmacotherapy

Year:

2019

Language:

english

File:

PDF, 2.39 MB

english, 2019

45

Complex Analysis of Fluorescence Intensity Fluctuations of Molecular Compounds

Yatskou, M. M., Skakun, V. V., Nederveen-Schippers, L., Kortholt, A., Apanasovich, V. V.

Journal:

Journal of Applied Spectroscopy

Year:

2020

File:

PDF, 1.83 MB

2020

46

The neuroprotective action of lenalidomide on rotenone model of Parkinson's Disease: Neurotrophic and supportive actions in the substantia nigra pars compacta

Cankara, Fatma Nihan, GÃ¼naydÄ±n, Caner, Bilge, SÃ¼leyman SÄ±rrÄ±, Ãzmen, Ãzlem, Kortholt, Arjan

Journal:

Neuroscience Letters

Year:

2020

File:

PDF, 5.34 MB

2020

47

The tale of proteolysis targeting chimeras (PROTACs) for leucineârich repeat kinase 2 (LRRK2)

Doemling, Alexander, Konstantinidou, Markella, Oun, Asmaa, Pathak, Pragya, Zhang, Bidong, Wang, Zefeng, ter Brake, Frans, Dolga, Amalia, Kortholt, Arjan

Journal:

Year:

2020

File:

PDF, 971 KB

2020

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